-- Yog-Sothoth --
The Doors of Time
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Type : Support
Cost : 1
Subtype : Environment.
Game Text: Action: exhaust and pay 1 to choose and destroy a Day card.
Flavor text: We adoreth you, Ament-Isis, secret Queen, and know through thee the paths through many gates.
Illustrator: Torstein Norstrand
Collector's Info: UT R108

-- Miskatonic University --
M.U. Science Building
---------------------
Type : Support
Cost : 2
Subtype : Location.
Game Text: Action: pay 2 to choose a character or support card. Until the end of the phase, that card gains a Subtype of your choice.
Flavor text:
Illustrator: Mike Yamada
Collector's Info: AE U58

obviously you have to drain two domains, but there are plenty of ways to gain an extra domain. both cards are cheap to play so you could get this working early. basically you could destory anything in the game with this combo, correct?

if i got this right i need to get some doors of time and a way to increase my chances of getting these cards on the table.

Sure, that works. I actually prefer the X cost night events from EE because of their speed and 0 cost, but The Doors of Time of course sticks on the table. And why not use both?