I think I thumped R'Lyeh on my about sixth try (random investigators; Mary, Lambeau, Simmons, Sharpe, last of whom was driven insane during phase two). Of course, when I sent Simmons to assail R'Lyeh...well, he got rather lucky with his die rolls, and I'd managed to have a good time margin to get all three amulet nodes.

Now, if the next update is going to have more Great Old Ones and worse...Given that the main milieu is a museum, where, exactly, is Chaugnar Faugn?! Although I suppose Rhan-Tegoth is also ideal bait under such a conceit.

Although, from what I've heard about "The Horror from the Hills"...perhaps the last phase of a Chaugnar campaign would be not sealing it, but actually hunting it down and destroying it...

 Ah, my bad. That does make Marie significantly more useful. I assumed her wild was strictly greens only. Whilst he can't pick up terrors, Wilding a yellow for free on the basis of having a yellow is still highly useful, and it's pretty hard to wind up in a situation where you lack such as long as you're careful. I'll give Marie a whirl later though.

Hobbesian said:

Don't pick an investigator.  Your chief R'lyeh-basher will be decided for you when someone gets the Cabala of Sabaoth, unless that investigator has less than 5 Sanity.  It's also worth killing off a couple of your other investigators so your superstar can take a shot at R'lyeh every day, healing Sanity and buying gear between each one. 

Meanwhile, I'm ready to confirm the game cheats if you do too well.  I took Jenny into R'lyeh with the Cabala and got stage 1 complete on the second conjure, using yellow and two greens.  I then rolled 27 dice without getting a single Terror for stage 2.  Hilariously, I won that game at 10 Doom with my last investigator who had no yellow glyph, no clues and only one lock, and would go mad if I failed.  Even more hilariously, the investigator you unlock for beating Cthulhu is the weakest in the entire game.

This is a woeful update to a fun game.  I have the card game and everyone I've played it with loves it.  Some elements of the card game were missing from Omens, such as allies and a final battle mechanic (which is why Azathoth was the only ancient one), but it was still surprisingly faithful to the card game and very enjoyable.  The update and the new Cthulhu "campaign" have ruined what was a fun game.  Instead of adding the missing elements of the card game they went in a completely different and poorly advised direction. 

• Too many "+3 Doom" mythos events at midnight (I've seen 3 in a row)
• "On entry" costs on adventure cards serve no purpose other than to make the game more difficult; they should at the very least be limited to part of the Cthulhu campaign, not present from the beginning of every game.
• New adventures are so difficult that they essentially require all glyphs be used to complete them with average luck
• Too many adventures lock glyphs - new adventures lock both the red and yellow glyphs; some games start with 3 glyphs locked
• After reaching the Cthulhu campaign, discovering R'lyeh and getting all gems for the amulet, the game will lock up on a load screen, unable to proceed

Fixing the bugs is one thing, and I expect FFG will do that, but they've made this game so maddeningly difficult that it's no longer fun.  The card game can get difficult if it gets away from you.  That's to be expected if you've ever played Arkham Horror.  But after the update, this game is incredibly difficult from the very start due to the preponderance of new, super-hard adventures and mythos events that punish, penalize or hamper any progress the investigators make.  If I could roll back to the previous version, I would.  Avoid this game in its current state.

Kastagir said:

What incredibly bad advice.

It's difficult, yes, but the new content alone makes it a no-brainer purchase for any fan of the game. And the difficulty itself is only found in certain areas: the Yig campaign is laughably easy, and Azathoth is still very winnable. It's really only the two-parter that ramps up the difficulty level. I've also yet to encounter a single bug in 20-plus games. Not one.

So it's pretty irresponsible of you to throw out "avoid!" as a piece of advice just because it's a tough game in places. I could just as easily say "Play better!" 

Kastagir said:

You know, there are certain strategies to the game. LEarn what investigators to use on what Adventures, when to use your items, what adventure to tackle and so forth.. Learn that, and it gets easier.

As the previous poster said. "Play Better"